Gene that Regulates Pain
Researchers found that pain scores from patients with sciatica and phantom limb pain were higher if they had the rare allele and even healthy women were more likely to have lower pain thresholds if they had the mutation. Additional experiments showed that inactivation of sodium channels is slower in cells with the rare allele.
Pain is subjective and often difficult to treat. Developing drugs that target the sodium channels might be useful in treating pain.