The answer to the image challenge this week is #1 - Atherosclerosis. Most of you got the right answer because you obviously know that the diagonal crease seen in the earlobe is known as "Frank's sign". The sign was originally described as a marker for coronary artery disease, with a moderate sensitivity ( approximately 48%) and specificity ( approximately 88%). Frank's sign has been associated with other cardiovascular risk factors like atherosclerosis.
Good job, readers! How many of you have looked in the mirror at your own earlobe?